17,234 research outputs found

    Laboratory tests in patients treated with isotretinoin: occurrence of liver and muscle abnormalities and failure of AST and ALT to predict liver abnormality.

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    Current laboratory monitoring may not be optimal. A retrospective chart review was performed on thelaboratory results of 246 patients who were treated with isotretinoin for acne over a 9-year period. Tests obtained were CBC, lipid panel, AST, ALT, CK, GGT,and C-reactive protein. Thirty-five patients had an elevated AST and 35 of these had an elevated CK; 32 had an elevated ALT and 11 of these had an elevated CK. Thirteen patients had an elevated GGT; in 5 this was the only abnormality, whereas 8 had a GGT elevation accompanied by an elevated AST or ALT. Two had an elevated GGT and an elevated CK with normal AST and ALT. Fifty-two patients had a single episode of elevated CK, of which 22 were female. However, 57 had multiple CK elevations and only one was female. Thirty-five patients had CK elevationsnormal; 38 had levels between 2 and 3 times normal, 18 had levels between 3 and 4 times normal, and 18 had levels greater than 4 times normal. We suggest that ALT and AST are not useful for monitoring isotretinoin therapy and that GGT and CK may be of greater value in managing patients

    Informality and the Development and Demolition of Urban Villages in the Chinese Peri-urban Area

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    The fate of Chinese urban villages (chengzhongcun) has recently attracted both research and policy attention. Two important unaddressed questions are: what are the sources of informality in otherwise orderly Chinese cities; and, will village redevelopment policy eliminate informality in the Chinese city? Reflecting on the long-established study of informal settlements and recent research on informality, it is argued that the informality in China has been created by the dual urban-rural land market and land management system and by an underprovision of migrant housing. The redevelopment of chengzhongcun is an attempt to eliminate this informality and to create more governable spaces through formal land development; but since it fails to tackle the root demand for unregulated living and working space, village redevelopment only leads to the replication of informality in more remote rural villages, in other urban neighbourhoods and, to some extent, in the redeveloped neighbourhoods. © 2012 Urban Studies Journal Limited

    Planting on Rural School Grounds

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    Smooth matter and source size in microlensing simulations of gravitationally lensed quasars

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    Several gravitationally lensed quasars are observed with anomalous magnifications in pairs of images that straddle a critical curve. Simple theoretical arguments suggest that the magnification of these images should be approximately equivalent, whereas one image is observed to be significantly demagnified. Microlensing provides a possible explanation for this discrepancy. There are two key parameters when modelling this effect. The first, the fraction of smooth matter in the lens at the image positions, has been explored by Schechter and Wambsganss (2002). They have shown that the anomalous flux ratio observed in the lensed quasar MG 0414+0534 is a priori a factor of 5 more likely if the assumed smooth matter content in the lens model is increased from 0% to 93%. The second parameter, the size of the emission region, is explored in this paper, and shown to be more significant. We find that the broadening of the magnification probability distributions due to smooth matter content is washed out for source sizes that are predicted by standard models for quasars. We apply our model to the anomalous lensed quasar MG 0414+0534, and find a 95% upper limit of 2.62 x 10^(16) h^(-1/2) (M/Msun)^(1/2) cm on the radius of the I-band emission region. The smooth matter percentage in the lens is unconstrained.Comment: 6 pages, 6 figures. To be published in MNRA

    Quantum Chemical Analysis of the Excited State Dynamics of Hydrated Electrons

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    Quantum calculations are performed for an anion water cluster representing the first hydration shell of the solvated electron in solution. The absorption spectra from the ground state, the instant excited states and the relaxed excited states are calculated including CI-SD interactions. Analytic expressions for the nonadiabatic relaxation are presented. It is shown that the 50fs dynamics recently observed after s->p excitation is best accounted for if it is identified with the internal conversion, preceded by an adiabatic relaxation within the excited p state. In addition, transient absorptions found in the infrared are qualitatively reproduced by these calculations
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